Effect of Voluntary Exercise Training on Corticosterone Level and Immobility Behavior Induced by Chronic Stress in Rats
Authors
Abstract:
Background: Depression is a common mood disorder that in the long-term impairs thoughts, behavior, feelings, and health. Chronic unpredictable stress is one of the factors that can cause depression. Objectives: To investigate the effect of voluntary exercise training on immobility behavior (caused by chronic unpredictable stress) and serum corticosterone concentration. Materials & Methods: A total of 24 male rats were randomly and equally assigned to four groups of healthy-control, healthy-exercise, depressed-control, and depressed-exercise. Depressed-control and depressed-exercise groups were first exposed to three weeks of chronic unpredictable stress. After this period, the exercise groups performed four weeks of voluntary exercise training. Twentyfour hours after the last training session, a forced swim test was taken from the rats and their blood samples were taken 24 hours later. The obtained data were analyzed using a 2-way analysis of variance (significance level: P<0.05). The Pearson correlation coefficient was used to examine the relationship between study variables. All statistical analyses were performed in SPSS v. 22. Results: Chronic stress increased immobility behavior (P=0.001) and serum corticosterone concentration (P=0.001). In contrast, exercise training reduced immobility behavior (P=0.001) and serum corticosterone (P=0.001). The immobility time (P=0.001) and serum corticosterone concentration in the depressed-exercise group were higher than those in the healthy-exercise group (P=0.001). There was a positive correlation between immobility behavior and serum corticosterone concentration (r=0.85 and P=0.001). Conclusion: While the chronic stress increases the immobility behavior and serum corticosterone concentration, voluntary exercise training can reduce immobility behavior and serum corticosterone and adjust some depression symptoms.
similar resources
the effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولeffect of listening strategy training on iranian efl learners listening comprehension and use of strategies
this study aimed to investigate the effects of listening strategy training on iranian efl learners listening comprehension and use of such strategies. this work, employing an experimental methodology, was conducted among 60 adult efl learners from a language institute in isfahan, iran, as participants. the participants, who were selected based on the results of a placement test, were assigned t...
15 صفحه اولP82: Comparison of the Effect of Stress & Exercise on Plasma Corticosterone & Hippocampal Apoptosis in the Female PTSD Rats
associated with inability to extinguish these fear memories, & hippocampal atrophy, & increase the risk of neurodegenerative disease. Studies showed that apoptosis is a neurodegenerative process that has important role in that ,although volume & function of hippocampus reduce by the chronic effect of glucocorticoids. Hippocampal steroid receptors control the HPA axis. Glucocorticoids involve in...
full textEffects of thymol on non-alcholic hepatic liver induced with chronic immobility in rats
Abstract Background and Aim: Considering the role of oxidative stress on non-alcoholic fatty liver disease and changing lipid profiles, the antioxidant effect of plants and fruits on biochemical indicators was investigated. Thymol is a phenolic monoterpene that has antioxidant properties. According to the above, in this study, the effects of thymol on improving the symptoms of non-alcoholic fa...
full textP 6: Effect of Voluntary Exercise on Learning and Memory Impairments in Sleep Deprived Female Rats
Introduction: Sleep disorders are common problems in modern societies affecting different aspects of individuals' lives. Many studies have reported that sleep deprivation (SD) leads to impairments in hippocampus-dependent learning and memory formations. Physical exercise has been shown to improve learning and memory. The objective of the current study was to investigate the effects of Voluntary...
full textThe Effect of Hydroalcoholic Extract of Perovskia Abrotanoides on Neuronal Density of Rats under Chronic Immobility Stress
Introduction: The number of neurons in the hippocampus can have a direct effect on its function. The plant Brazembel from the mint family may have antioxidant properties. The aim of the present study was to investigate the effects of stress and Brazmble extract on neuronal density of CA1, CA2 in male rats. Methods: In this experimental study, Wistar rats were divided into 6 groups (n=5), inclu...
full textMy Resources
Journal title
volume 6 issue 3
pages 164- 169
publication date 2020-07
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023